The Problem

 

Altitude and oxidative stress

Models of hypoxia/reperfusion have shown the increase of reactive substances derived from oxygen in the hypoxia phase and in the reperfusion phase (Gao,1996; Boiling,1997; Singh, 1995; Oillet, 1996; Paller, 1995)

Hypo baric hypoxia produces the increase of Malondialdehid in eritrocits and plasma of rabbits. This effect is prevented with vitamin E and/or dismutasa super oxide (Han, 1995)

Vitamin E avoids the increasing of ethane exhalation (metabolite of lipidic peroxidation ) in climbers submitted to this exercise at 5100 meters and it improves its performance at this altitude. (Simon-Schnass, 1992)

 

Reactive Substances Derived from Oxygen (RSDO)

 

Normally between 2 and 5% of received oxygen at cell level generates RSDO (Mc Ardle, 1996)

They are molecules or fragments of molecules with an unpaired electron in its external orbit, highly reactive, that look for balancing its electronic unbalance.

 

 

Exhalation of Etano in Exercise

 

Nutrition at Higgh Altitude. Simon-Schnass I. 1992